Watterson equation

s ~ theta * sequence (in bp) * (ln(n-1) + 0.52)

Where n = number of chromosomes.

common numbers

About 10,000 variants in a single exome (theta ~ 3e-4).

About 3 million variants per genome (theta ~ 1e-3); actually less becuase theta for exonic sequence ought to be lower.

  • Watterson GA. (1975) On the Number of Segregating Sites in Genetical Models without Recombination. Theoretical Population Biology 7, 256-276.