s ~ theta * sequence (in bp) * (ln(n-1) + 0.52)
n = number of chromosomes.
10,000 variants in a single exome (
theta ~ 3e-4).
3 million variants per genome (
theta ~ 1e-3); actually less becuase theta for exonic sequence ought to be lower.
- Watterson GA. (1975) On the Number of Segregating Sites in Genetical Models without Recombination. Theoretical Population Biology 7, 256-276.